PhD
DISSERTATION:
My PhD work in the Cognition and Addiction Biopsychology Lab at UNC Chapel Hill (PI: Charlotte Boettiger, PhD) focused on delay discounting behavior in human subjects. Delay discounting occurs when people discount future rewards and is a behavior believed to be more severe in problem drug users (they discount the future more severely than age-matched controls).
My work at UNC used behavioral genetic approaches to understand the role of prefrontal cortex dopamine as a modulator of delay discounting behavior and the potential for this behavior to serve as an intermediate phenotype for alcohol use disorders.
My PhD work in the Cognition and Addiction Biopsychology Lab at UNC Chapel Hill (PI: Charlotte Boettiger, PhD) focused on delay discounting behavior in human subjects. Delay discounting occurs when people discount future rewards and is a behavior believed to be more severe in problem drug users (they discount the future more severely than age-matched controls).
My work at UNC used behavioral genetic approaches to understand the role of prefrontal cortex dopamine as a modulator of delay discounting behavior and the potential for this behavior to serve as an intermediate phenotype for alcohol use disorders.
Links to Published Research Work
| Fernandes et al 2020, eLife, A survey-based analysis of the academic job market |
| Juarez et al 2019, Psychology and Aging, Reproducibility of the Correlative Triad Among Aging, Dopamine Receptor Availability, and Cognition |
| Seaman et al 2019, Human Brain Mapping, Differential Regional Decline in Dopamine Receptor Availability Across Adulthood |
Seaman et al 2019, Link to interactive data visualization tool.
| Smith et al 2018, Translational Psychiatry, Ventral striatal dopamine transporter availability is associated with lower trait motor impulsivity |
| Smith et al 2018, Translational Psychiatry, Supplementary Material |
Raw data available at https://osf.io/324tw/
Unthresholded statistical parametric maps are available at: https://neurovault.org/collections/3911/
Unthresholded statistical parametric maps are available at: https://neurovault.org/collections/3911/
| Smith et al 2018, Psychopharmacology, Lack of consistent sex differences in d-amphetamine-induced dopamine release |
Raw data available at https://osf.io/24zxk/
Unthresholded statistical parametric maps are available at: https://neurovault.org/collections/4040/ (Dataset 1),
https://neurovault.org/collections/4041/ (Dataset 2)
Unthresholded statistical parametric maps are available at: https://neurovault.org/collections/4040/ (Dataset 1),
https://neurovault.org/collections/4041/ (Dataset 2)
| Castrellon et al 2019, J Neurosci, Individual Differences in Dopamine Associated with Reward Discounting in Clinical Groups but Not Healthy Adults |
Supplemental analyses and data available at https://osf.io/htq56/
Unthresholded statistical parametric maps are available at: https://neurovault.org/collections/ZPFBVXPK/
Unthresholded statistical parametric maps are available at: https://neurovault.org/collections/ZPFBVXPK/
| Stark et al 2018, J Neurosci, D2/3 Receptor Expression in Parkinson's Disease Patients with Compulsive Reward-Driven Behaviors |
| Stark et al 2018, Neuroimage: Clinical, Fallypride Characterization of Striatal and Extrastriatal D2/3 Receptors in Parkinson's Disease |
| Dang et al 2017, Physiology & Behavior, FTO Affects Food Cravings and Interacts with Age to Influence Age-related Decline in Food Cravings |
| Elton et al 2017, Frontiers in Human Neuroscience, COMT Val158Met Exerts Sex-Dependent Effects On Brain Function |
| Elton et al 2017, Frontiers in Human Neuroscience, Supplementary Material |
| Smith et al 2017, JCBFM, PVC Increases Estimated Dopamine D2-like Receptor Binding Potential and Reduces Adult Age Differences |
| Smith et al 2017, JCBFM, Supplementary Material |
| Smith et al 2017, Translational Psychiatry, Impact of Common Dopamine D2 Receptor Gene Polymorphisms on D2/3 Receptor Availability |
| Smith et al 2017, Translational Psychiatry, Supplementary Material |
| Elton et al 2017, Journal of Cognitive Neuroscience, Neural Systems Underlying Individual Differences in Intertemporal Decision-making |
| Smith et al 2016, Neuropharmacology, Variability in Paralimbic DA Signaling and Subjective Responses to dAMPH |
| Smith et al 2016, Neuropharmacology, Supplementary Material |
| Smith et al 2016, Journal of Neurophysiology, Modulation of Impulsivity & Reward Sensitivity in Intertemporal Choice by Striatal & Midbrain DA |
| Smith et al 2016, Journal of Psychopharmacology, Individual Differences in Timing of Peak Positive Subjective Responses to d-amphetamine |
| Smith et al 2016, Journal of Psychopharmology Supplementary Material |
| Smith et al 2015, Frontiers in Human Neuroscience, Intertemporal Choice Behavior in Emerging Adults and Adults |
| PhD Dissertation |
| Smith et al 2014, Journal of Neuroscience, Ovarian Cycle Effects on Immediate Reward Selection Bias: A role for estradiol |
| Smith et al 2014, Journal of Cognitive Neuroscience, Frontal Dopamine Genetics and Target Detection Under High Working Memory Load |
| Smith et al 2014, Journal of Cognitive Neuroscience Supplementary Material |
| Swift Scanlan et al 2014, BMC Medical Genomics, Compressive Interrogation of CpG Island Methylation in the COMT Gene |
| Smith and Boettiger 2012, Psychopharmacology, Age Modulates the Effect of COMT Genotype on Delay Discounting Behavior |
CV
| Chris_Smith_CV_May_2023.pdf |